Toronto FC (5-13-6, 11th in the Eastern Conference) vs. Philadelphia Union (15-5-5, first in the Eastern Conference) ...

Nashville SC (14-6-5, first in the Western Conference) vs. Saint Louis City SC (4-14-6, 15th in the Western Conference) ...

Los Angeles FC (10-6-6, seventh in the Western Conference) vs. Chicago Fire (10-9-5, eighth in the Eastern Conference) ...

San Diego FC (14-7-4, second in the Western Conference) vs. Sporting Kansas City (6-12-6, 14th in the Western Conference) ...

Houston Dynamo (7-11-6, 12th in the Western Conference) vs. Austin FC (9-8-6, eighth in the Western Conference) ...